1. Role of chromatin regulators associated with autism mutations in activity-dependent circuit development

Autism Center

Our interactions with the outside world trigger changes in neurons that are critical for proper brain development and higher cognitive function. Experience-driven neuronal activity shapes gene expression in ways that promote the maturation and refinement of neural circuits.

Recent large-scale human genomic sequencing studies have revealed that genes encoding chromatin regulators are frequently mutated in ASD.

Mutations in genes encoding chromatin regulators often show neurological abnormalities as their most pronounced consequence. Our work is broadly focused on investigating the cellular functions of autism-associated gene regulatory factors. A family of disorders termed chromatinopathies, often present with features such as developmental delay, intellectual disability, and behavioral abnormalities.

As these processes are closely connected to numerous human cognitive disorders, we are committed to using our molecular discoveries to deepen our understanding of clinically significant neurological conditions.

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2. Experience-driven Hypothalamic-Pituitary-Adrenal axis signaling in central and peripheral circuit maturation

Brain Body Center

The brain and body interact through intricate signaling networks composed of the nervous and endocrine systems. This two-way communication governs vital processes such as movement, mood, metabolism, and homeostasis, yet the detailed mechanisms underlying brain-body signaling during development are not yet fully understood.

Corticosterone (CORT), the main glucocorticoid hormone produced by the adrenal cortex, is a central output of the hypothalamic-pituitary-adrenal (HPA) axis in response to stress and other stimuli. CORT is essential for regulating metabolism, supporting immune function, and enabling the body to adapt to stressful conditions.

After eye opening, light exposure triggers the adrenal gland to release CORT, and  ongoing daily cycles of circulating CORT are subsequently maintained by the central circadian clock.

Understanding how these signaling pathways are altered during development due to changes in gene expression will offer important insights into health, disease, and the body’s response to stress throughout life.